Technical Poster Request

Poster Abstract:

Benzodiazepines are among the most often prescribed drugs in the US with significant abuse potential. Analogs to the prescription class of benzodiazepines, often obtained on illicit marketplaces, are not U.S. Food and Drug Administration (FDA) approved and are increasingly finding their place among the population over the last two decades. These designer benzodiazepine substances retain the core structure of the approved benzodiazepines but, some functional groups are altered. This allows them to evade legal restrictions while keeping the desired mind-altering effects. It is important to be able to track these substances as they arise so they can be monitored and detected. Due to cross reactivity of these analogs with benzodiazepine immunoassay kits, developing effective LC-MS/MS techniques is increasingly important for proper identification and quantitation. In this study, we focused on 14 compounds in a urine matrix utilizing a high sensitivity, fast (less than 4 minutes) LC analysis. The panel comprises of 13 designer benzodiazepines. Alprazolam was also included because it is an isomer to Deschloroetizolam and LC separation is necessary. Solid phase extraction (SPE) was used for sample cleanup to achieve a low limit of detection. A high efficiency 2.6 µm, 50 x 3.0 mm Kinetex™ Biphenyl LC column was used for chromatographic separation, coupled with a SCIEX® Triple Quad™ 4500 system for MS/MS detection.

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