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Fundamentals First Bio Series: A Beginner’s Roadmap to mAb CQAs and LC Workflows

This webinar introduces the fundamentals of monoclonal antibody (mAb) Critical Quality Attributes (CQAs) and the LC workflows commonly used to assess them. We’ll begin with an overview of mAb heterogeneity and the major CQA categories, including size, charge, hydrophobic and structural variants, plus common post-translational modifications.

The session will then connect these CQAs to the chromatographic techniques most commonly used for characterization, including size exclusion chromatography (SEC), ion exchange chromatography (IEX), and reversed-phase LC (RPLC). Attendees will gain a practical understanding of what each technique measures, how the methods complement one another, and why they are important in biopharmaceutical analysis.

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