Join Our FREE Live Webinar!
mRNA Characterization - From 5’ Cap to Poly (A): What IPRP–MS Can Tell You
Roxana Eggleston-Rangel
Senior Applications Scientist, Phenomenex
Thursday, July 11, 2024
10:00 AM - 11:00 AM (PT)
Event Overview:
- In this webinar, we present an mRNA characterization workflow that includes sample preparation, LC-MS methodology and bioinformatics processing for the evaluation of 5' Cap efficiency, mapping of oligonucleotide sequence fragments, isomer resolution and Poly (A) tail intact mass analysis.
Who Should Attend:
- Researchers and Scientists: Ideal for those seeking to expand their insights into LC-MS characterization techniques and applications of mRNA modifications.
- Quality Control and In-Process Testing Professionals: Recommended for professionals involved in quality control, in-process testing, or analytical development.
- Biopharmaceutical Industry Professionals: Valuable for those evaluating and optimizing their current mRNA-based therapeutics development and characterization solutions.
Key Learning Points:
- Explore the LC-MS characterization method for 5' Cap, coding sequence mapping, and Poly(A) tail analysis.
- Gain insights into utilizing ion-pairing reversed-phase LC-MS to characterize mRNA drug substances.
- Discover the benefits of utilizing BioTi core-shell column technology to improve sensitivity and resolution for oligonucleotide identification.
- Review of bioinformatics processing workflow
