Date and Location
On site or Online - on demand
Course Summary
Validated methods ensure the quality of your analytical results, but often prevent the use of innovative column technologies. In this seminar, we will show you how to optimize QC methods within the scope of the allowed adjustments according to the European and US Pharmacopeia. We pay special attention to the conditions under which this is possible without a complete revalidation of the method.
Course Outline
- What should be considered when optimizing validated methods
- Criteria for the system suitability test
- Selection of the right column for a monographic method
- Allowed adjustments of chromatographic conditions
- The new harmonization between Ph. Eur. and USP
- Regulations for isocratic and gradient elution in HPLC
- Method optimization through variation of particle size, particle morphology, column length, and flow rate
- Use of new column technologies for pharmacopeia methods
- Influence of the mobile phase on method robustness
- Various case studies to clarify and deepen the content
- Optimization exercises and troubleshooting
- Special regulations for GC methods
Practical Skills Acquired
This course will enable you to use the allowed adjustments of Pharmacopeias to:
- Increase chromatographic efficiency and reduce runtimes
- Increase laboratory productivity and reduce costs
- Improve the quality of analytical results
- Fulfill the SST criteria more easily
- Troubleshoot non-robust QC methods
Is this seminar of interest to your lab? Please contact your local Technical Sales
Consultant or email phenomenexeu@phenomenex.com to request a seminar.
Have a question about these seminars? Please contact us
Nordic Office
DK: 4824 8048 | NO: +47 810 02 005SE: 08 611 6950 | FI: +358 (0)9 4789 0063
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