Comparing Selectivity of Core-Shell and Modified Fully Porous HPLC Columns to Optimize Separation of 3 Classes of 47 TDM Analytes.

Poster Abstract

Therapeutic drug monitoring (TDM) research requires quantitation within narrow concentration ranges to distinguish between acceptable and toxic drug concentrations that

could trigger potential adverse effects. For proper identification and measurement, a panel comprised of 47 analytes, subdivided into three categories: 22 Antidepressants, 14

Antipsychotics, and 11 Anticonvulsants were targeted. Here, a parallel comparison of two LC phases, a Kinetex™ 2.6 µm Biphenyl and a Luna™ Omega 3 µm Polar C18 both in 50

x 3.0 mm column dimensions packed with modified fully porous and core-shell and fully porous particles respectively, was conducted. The best selectivity and conditions for fast

LC separation while achieving baseline resolution of critical isobaric compounds in each drug class was determined.

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