Peak Shape Problems...

Gas Chromatography Technical Tip

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Sensitivity Loss: Some or all of your peaks are displaying decreased response. What is going on and how can you remedy this issue?

Symptom Possible Cause Suggested Remedy
Decreased Response Contamination of column and/ or liner can lead to loss of sensitivity for active compounds. Clean liner. See injector maintenance.
Bake out the column. Solvent rinse or replace the column. See column installation.
Injector leaks reduce the peak height of the most volatile components of a sample. Find and fix any leaks.
If initial column temperature is too high for splitless injection, this prevents refocusing of sample. This affects the more volatile components most. Lower temperature below the boiling point of the solvent. Decrease the initial column temperature, or use a less volatile solvent
Inlet discrimination: injector temperature is too low. Later eluting and less volatile compounds have low response. Increase the injection temperature or use on-column injection with direct connect liner.
Issues with the sample Check the sample concentration, any sample preparation procedures, and shelf life. Prepare a fresh sample ensuring the proper concentration.

GC Column Selection and Gas Management Poster

Side 1: Tips and Steps for selecting the correct Gas Management Filters for your GC or LC system; And Inline Gas Traps for your GC or GC-MS system.

    Side 2: Guidelines for your GC column selection process:
  • The Master Resolution Equation
  • Internal Diameter
  • Film Thickness
  • Length
  • Column Phase

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